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Synthesis
DOI: 10.1055/a-2705-4229
DOI: 10.1055/a-2705-4229
Paper
Total Synthesis of Vestitol and Medicarpin
Authors
We thank Innovation Team of Guangdong Education Department (No. 2022KCXTD054), Guangdong Basic and Applied Basic Research Foundation (No. 2022A1515111032) and Shenzhen Science and Technology Innovation Committee (No. 20220815100042003) for the financial support.
Supported by: Innovation Team of Guangdong Education Department 2022KCXTD054
Abstract
Total synthesis of vestitol and medicarpin, two isoflavonoids with distinct skeletons, was successfully achieved using a single intermediate as the starting point. This six-step synthetic approach features a BBr3-promoted tandem O-demethylation/cyclization reaction, which enables the rapid construction of the pterocarpan core structure. Subsequently, a Pd/C-catalyzed hydrogenation/hydrogenolysis reaction was employed to respectively synthesize vestitol and medicarpin.
Publication History
Received: 03 June 2025
Accepted after revision: 29 August 2025
Accepted Manuscript online:
19 September 2025
Article published online:
09 October 2025
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